The Scottish striker has more or less missed ten months of action with knee injuries but he could be named as a substitute for the big derby class at Elland Road.
MacLean has not played for Wednesday since damaging ligaments and breaking his leg in the pre-season friendly with Manchester City.
But Paul Sturrock must also decide whether to play Nicky Weaver in what will be the last game of his loan spell or recall David Lucas.
Glenn Whelan limped off against Leicester City last weekend with a dead leg but should be fit for the game after resuming training yesterday.
Meanwhile, former Gillingham star Hills believes Wednesday can go in to the match in confident mood, despite all the pressure being on the hosts.
He told Footymad: "It is a big game; obviously we will go in with confidence from the last three league games. But we know we beat Leeds at home earlier in the season and they are just coming off the back of a bad result against Brighton so the pressure is really on them as far as we are concerned so it’s a good game for us and hopefully we can get another victory."
Gilbert agrees, he said: "It’s a massive game away at Leeds and it’s another one we need to win. We have three wins on the bounce so that gives us confidence to win more, if we do then we have a bit of breathing room from the bottom teams so that’s what we have to do.
"Leeds have got a fantastic squad there with some very capable players but we have to go there, be confident, keep playing like we have been playing and I am sure that we will get something up there."