The striker, still to find good goal scoring form for The Owls was taken off on 35 minutes with a back injury.
Luton's Warren Feeney replaced the former Willem II man in Northern Ireland's 1-0 defeat in Poland.
Quinn could have scored early in the first half but he was denied a goal on his return to the team by Liverpool's Jerzy Dudek.
If Quinn does miss out on Saturday, it will put more pressure on Lee Peacock, Graham Barrett and Drew Talbot to provide the firepower for Paul Sturrock's men for arguably their biggest game of the season.